{"id":30939,"date":"2022-08-12T10:37:00","date_gmt":"2022-08-12T16:37:00","guid":{"rendered":"https:\/\/brakkeconsulting.com\/?p=30939"},"modified":"2022-08-12T10:37:14","modified_gmt":"2022-08-12T16:37:14","slug":"brakke-viewpoint-august-12-2022","status":"publish","type":"post","link":"https:\/\/brakkeconsulting.com\/zh\/brakke-viewpoint-august-12-2022\/","title":{"rendered":"\u5e03\u62c9\u514b\u89c2\u70b9 2022 \u5e74 8 \u6708 12 \u65e5"},"content":{"rendered":"<p>\u6211\u4eec\u4e0d\u5e94\u8be5\u653e\u5f03\u7814\u53d1\u9488\u5bf9ASF\u7684\u5f31\u6bd2\u6d3b\u75ab\u82d7\u3002<\/p>\n<p>\u5728\u6700\u8fd1\u4e0e\u4e2d\u56fd\u56fd\u5185\u5916\u52a8\u7269\u4fdd\u5065\u516c\u53f8\u7814\u53d1\u8d1f\u8d23\u4eba\u7684\u4f1a\u8bae\u4e2d\uff0c\u7ecf\u5e38\u8ba8\u8bba\u975e\u6d32\u732a\u761f (ASF) \u51cf\u6bd2\u6d3b\u75c5\u6bd2 (MLV) \u75ab\u82d7\u7684\u8bdd\u9898\u3002\u5927\u591a\u6570\u516c\u53f8\u9886\u5bfc\u90fd\u4e0d\u76f8\u4fe1 MLV \u75ab\u82d7\u4f1a\u5f88\u5feb\u83b7\u5f97\u4e2d\u56fd\u76d1\u7ba1\u673a\u6784\u7684\u6279\u51c6\u3002\u4ed6\u4eec\u6700\u62c5\u5fc3\u7684\u662f MLV \u75ab\u82d7\u7684\u5b89\u5168\u6027\u3002<\/p>\n<p>\u8fc7\u53bb\u51e0\u5e74\uff0c\u4e2d\u56fd\u672a\u7ecf\u6388\u6743\u5f15\u8fdb\u4e86\u591a\u79cd\u51cf\u6bd2\u975e\u6d32\u732a\u761f\u75c5\u6bd2\u682a\u4f5c\u4e3a\u5b9e\u9a8c\u6027\u75ab\u82d7\uff0c\u8fd9\u6e05\u695a\u5730\u8bc1\u660e\u4e86\u975e\u6d32\u732a\u761f\u5f31\u6bd2\u75ab\u82d7\u7684\u5371\u9669\u6027\u3002\u8fd9\u4e9b\u201c\u6bd2\u6027\u8f83\u4f4e\u201d\u7684\u5f31\u6bd2\u682a\u9020\u6210\u7684\u5371\u5bb3\u6bd4\u91ce\u751f\u578b\u975e\u6d32\u732a\u761f\u75c5\u6bd2\u66f4\u5927\uff0c\u56e0\u4e3a\u8fd9\u79cd\u75be\u75c5\u5728\u732a\u957f\u5927\u5e76\u53d7\u5230\u5e94\u6fc0\u65f6\u4f1a\u53d1\u5c55\u6210\u4e34\u5e8a\u75c7\u72b6\u3002<\/p>\n<p>\u7136\u800c\uff0c\u6211\u4eec\u4e0d\u5e94\u653e\u5f03\u7814\u5236\u51fa\u5b89\u5168\u6709\u6548\u7684 ASF MLV \u75ab\u82d7\u7684\u5e0c\u671b\u3002\u6bd5\u7adf\uff0c\u5b89\u5168\u6709\u6548\u7684 C \u682a\u732a\u761f (CSF) \u75ab\u82d7\u662f\u4e00\u79cd MLV \u75ab\u82d7\uff0c\u8fc7\u53bb\u51e0\u5341\u5e74\u6765\uff0c\u5b83\u5df2\u5728\u8bb8\u591a\u56fd\u5bb6\u6210\u529f\u7528\u4e8e\u63a7\u5236 CSF\u3002\u7531\u4e8e MLV \u75ab\u82d7\u901a\u5e38\u53ea\u6ce8\u5c04\u4e00\u6b21\uff0c\u800c\u4e14\u6bd4\u4e9a\u5355\u4f4d\u75ab\u82d7\u66f4\u6709\u6548\uff08\u514d\u75ab\u8d77\u6548\u66f4\u5feb\uff0c\u4fdd\u62a4\u671f\u66f4\u957f\uff09\uff0c\u56e0\u6b64\u4e0e\u5176\u4ed6\u7c7b\u578b\u7684\u75ab\u82d7\u76f8\u6bd4\uff0c\u5b83\u4eec\u901a\u5e38\u662f\u9884\u9632\u548c\u63a7\u5236\u4f20\u67d3\u75c5\u7684\u66f4\u5177\u6210\u672c\u6548\u76ca\u7684\u5de5\u5177\u3002\u5982\u679c MLV ASF \u75ab\u82d7\u5177\u6709\u4e0e C \u682a CSF \u75ab\u82d7\u76f8\u4f3c\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff0c\u5219\u5e94\u6279\u51c6\u7528\u4e8e ASF \u7684\u63a7\u5236\u548c\u9884\u9632\u3002<\/p>\n<p><em>\u6280\u672f\u5ba4<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>\u6211\u4eec\u4e0d\u5e94\u653e\u5f03\u5f00\u53d1\u975e\u6d32\u732a\u761f\u5f31\u6bd2\u6d3b\u75ab\u82d7\u3002\u6700\u8fd1\uff0c\u5728\u4e0e\u4e2d\u56fd\u56fd\u5185\u5916\u52a8\u7269\u4fdd\u5065\u516c\u53f8\u7814\u53d1\u8d1f\u8d23\u4eba\u7684\u4f1a\u8bae\u4e2d\uff0c\u975e\u6d32\u732a\u761f (ASF) \u5f31\u6bd2\u6d3b\u75ab\u82d7 (MLV) \u7684\u8bdd\u9898\u88ab\u9891\u7e41\u8ba8\u8bba\u3002\u5927\u591a\u6570\u516c\u53f8\u8d1f\u8d23\u4eba\u8ba4\u4e3a\uff0c\u4e2d\u56fd\u76d1\u7ba1\u673a\u6784\u8fd1\u671f\u4e0d\u4f1a\u6279\u51c6 MLV \u75ab\u82d7\u3002\u4ed6\u4eec\u4e3b\u8981\u62c5\u5fc3\u7684\u662f MLV \u75ab\u82d7\u7684\u5b89\u5168\u6027\u3002\u8fc7\u53bb\u51e0\u5e74\uff0c\u4e2d\u56fd\u672a\u7ecf\u6388\u6743\u5f15\u8fdb\u5404\u79cd\u975e\u6d32\u732a\u761f\u5f31\u6bd2\u682a\u4f5c\u4e3a\u5b9e\u9a8c\u6027\u75ab\u82d7\uff0c\u8fd9\u6e05\u695a\u5730\u8bc1\u660e\u4e86 ASF MLV \u75ab\u82d7\u7684\u5371\u9669\u6027\u3002\u8fd9\u4e9b\u201c\u4f4e\u6bd2\u529b\u201d\u7684 MLV \u6bd2\u682a\u6bd4\u91ce\u751f\u578b ASFV \u9020\u6210\u7684\u5371\u5bb3\u66f4\u5927\uff0c\u56e0\u4e3a\u8fd9\u79cd\u75be\u75c5\u4f1a\u5728\u732a\u53ea\u957f\u5927\u5e76\u53d7\u5230\u5e94\u6fc0\u65f6\u53d1\u5c55\u6210\u4e34\u5e8a\u75c7\u72b6\u3002\u7136\u800c\uff0c\u6211\u4eec\u4e0d\u5e94\u653e\u5f03\u7814\u5236\u5b89\u5168\u6709\u6548\u7684 ASF MLV \u75ab\u82d7\u7684\u5e0c\u671b\u3002\u6bd5\u7adf\uff0c\u5b89\u5168\u6709\u6548\u7684C\u682a\u732a\u761f\uff08CSF\uff09\u75ab\u82d7\u662f\u4e00\u79cd\u5f31\u6bd2\u6d3b\u75ab\u82d7\uff08MLV\uff09\uff0c\u5e76\u4e14\u5728\u8fc7\u53bb\u51e0\u5341\u5e74\u4e2d\u5df2\u5728\u8bb8\u591a\u56fd\u5bb6\u6210\u529f\u7528\u4e8e\u63a7\u5236CSF\u3002\u7531\u4e8e\u5f31\u6bd2\u6d3b\u75ab\u82d7\u901a\u5e38\u53ea\u9700\u63a5\u79cd\u4e00\u6b21\uff0c\u5e76\u4e14\u6bd4\u4e9a\u5355\u4f4d\u75ab\u82d7\u66f4\u6709\u6548\uff08\u514d\u75ab\u8d77\u6548\u66f4\u5feb\uff0c\u4fdd\u62a4\u671f\u66f4\u957f\uff09\uff0c\u56e0\u6b64\u4e0e\u5176\u4ed6\u7c7b\u578b\u7684\u75ab\u82d7\u76f8\u6bd4\uff0c\u5b83\u4eec\u901a\u5e38\u662f\u66f4\u5177\u6210\u672c\u6548\u76ca\u7684\u4f20\u67d3\u75c5\u9632\u63a7\u5de5\u5177\u3002<\/p>\n<div class=\"view-full-post\"><a href=\"https:\/\/brakkeconsulting.com\/zh\/brakke-viewpoint-august-12-2022\/\" class=\"view-full-post-btn\">\u67e5\u770b\u5b8c\u6574\u6587\u7ae0<\/a><\/div>\n<p>;<\/p>","protected":false},"author":19,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[43],"tags":[],"class_list":["post-30939","post","type-post","status-publish","format-standard","hentry","category-viewpoints"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>News from Brakke Consulting<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/brakkeconsulting.com\/zh\/brakke-viewpoint-august-12-2022\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"News from Brakke Consulting\" \/>\n<meta property=\"og:description\" content=\"We should not give up on developing a MLV vaccine for ASF. In recent meetings with R&amp;D leaders of domestic and international animal health companies in China, the topic of a modified live virus (MLV) vaccine for African Swine Fever (ASF) was often discussed. Most of these company leaders do not believe that an MLV vaccine will be approved by the Chinese regulatory agency anytime soon. The major concern is the safety of MLV vaccines. The danger of an ASF MLV vaccine has been clearly demonstrated by the unauthorized introduction of various attenuated ASF viral strains as experimental vaccines in China in the last few years. These &#8220;less-virulent&#8221; MLV strains caused more damage than the wildtype ASFV because the disease became clinical when pigs grew older and were stressed. However, we should not give up the hope that a safe and efficacious MLV vaccine for ASF is possible. Afterall, the safe and efficacious C-strain Classical Swine Fever (CSF) vaccine is an MLV vaccine and it has been successfully used to control CSF in many countries in the last few decades. 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Afterall, the safe and efficacious C-strain Classical Swine Fever (CSF) vaccine is an MLV vaccine and it has been successfully used to control CSF in many countries in the last few decades. 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