{"id":33429,"date":"2024-03-28T21:14:56","date_gmt":"2024-03-29T03:14:56","guid":{"rendered":"https:\/\/brakkeconsulting.com\/?p=33429"},"modified":"2024-03-28T21:14:56","modified_gmt":"2024-03-29T03:14:56","slug":"brakke-viewpoint-march-29-2024","status":"publish","type":"post","link":"https:\/\/brakkeconsulting.com\/pt\/brakke-viewpoint-march-29-2024\/","title":{"rendered":"Mirante de Brakke 29 de mar\u00e7o de 2024"},"content":{"rendered":"<p>O que voc\u00ea pensa quando v\u00ea um porco? Voc\u00ea come\u00e7a a salivar pensando em bacon, presunto, uma costeleta de porco grande e suculenta ou um peda\u00e7o de costela? Rick Slayman, um residente de Massachusetts de 62 anos com doen\u00e7a renal em est\u00e1gio terminal, v\u00ea os porcos como uma passagem potencial para uma vida livre de di\u00e1lise.<\/p>\n<p>Em 21 de mar\u00e7o, os m\u00e9dicos do Mass General Hospital realizaram o primeiro transplante de um rim geneticamente modificado de um porco. De acordo com a Rede de Aquisi\u00e7\u00e3o e Transplante de \u00d3rg\u00e3os, aproximadamente 27 mil rins foram transplantados em 2023. No entanto, a lista de espera para rins humanos tem aproximadamente 89 mil indiv\u00edduos. Basta pensar em quantas pessoas poderiam viver uma vida produtiva, feliz e saud\u00e1vel se esta opera\u00e7\u00e3o fosse um sucesso total. Isto poderia potencialmente eliminar a maior barreira ao transplante, que \u00e9 o fornecimento de \u00f3rg\u00e3os.<\/p>\n<p>O obst\u00e1culo mais cr\u00edtico ao uso de \u00f3rg\u00e3os de animais em humanos \u00e9 a rejei\u00e7\u00e3o de \u00f3rg\u00e3os. O rim utilizado neste procedimento foi geneticamente modificado pela eGenesis Bio para aumentar a compatibilidade humana. A eGenesis empregou nova tecnologia para fazer 69 edi\u00e7\u00f5es precisas no DNA do porco (cortando certas caracter\u00edsticas e acrescentando outras) para tentar evitar que o corpo humano veja o rim como um corpo estranho. Isso, combinado com tratamentos com anticorpos monoclonais para reduzir a probabilidade de rejei\u00e7\u00e3o, fornece um caminho poss\u00edvel para o transplante de \u00f3rg\u00e3os animais.<\/p>\n<p>Pense novamente enquanto olha para aquele peda\u00e7o de costela envolta em molho de churrasco. Os porcos podem n\u00e3o apenas ser um suprimento sustent\u00e1vel de alimentos, mas tamb\u00e9m fornecer uma fonte extremamente cr\u00edtica de \u00f3rg\u00e3os para pacientes humanos em cuidados intensivos.<\/p>\n<p><em>Randy Freides<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>O que voc\u00ea pensa quando v\u00ea um porco? Voc\u00ea come\u00e7a a salivar pensando em bacon, presunto, uma costeleta de porco grande e suculenta ou um peda\u00e7o de costela? Rick Slayman, um residente de Massachusetts de 62 anos com doen\u00e7a renal em est\u00e1gio terminal, v\u00ea os porcos como uma passagem potencial para uma vida livre de di\u00e1lise. Em 21 de mar\u00e7o, os m\u00e9dicos do Mass General Hospital realizaram o primeiro transplante de um rim geneticamente modificado de um porco. De acordo com a Rede de Aquisi\u00e7\u00e3o e Transplante de \u00d3rg\u00e3os, aproximadamente 27 mil rins foram transplantados em 2023. No entanto, a lista de espera para rins humanos tem aproximadamente 89 mil indiv\u00edduos. Basta pensar em quantas pessoas poderiam viver uma vida produtiva, feliz e saud\u00e1vel se esta opera\u00e7\u00e3o fosse um sucesso total. Isto poderia potencialmente eliminar a maior barreira ao transplante, que \u00e9 o fornecimento de \u00f3rg\u00e3os. O obst\u00e1culo mais cr\u00edtico ao uso de \u00f3rg\u00e3os de animais em humanos \u00e9 a rejei\u00e7\u00e3o de \u00f3rg\u00e3os. O rim utilizado neste procedimento foi geneticamente modificado pela eGenesis Bio para aumentar a compatibilidade humana. A eGenesis empregou nova tecnologia para fazer 69 edi\u00e7\u00f5es precisas no DNA do porco (cortando certas caracter\u00edsticas e acrescentando outras) para tentar evitar que o corpo humano veja o rim como um corpo estranho. Isso, combinado com tratamentos com anticorpos monoclonais para reduzir a probabilidade de rejei\u00e7\u00e3o, fornece um caminho poss\u00edvel para o transplante de \u00f3rg\u00e3os animais. Pense de novo<\/p>\n<div class=\"view-full-post\"><a href=\"https:\/\/brakkeconsulting.com\/pt\/brakke-viewpoint-march-29-2024\/\" class=\"view-full-post-btn\">Ver postagem completa<\/a><\/div>\n<p>;<\/p>","protected":false},"author":19,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[43],"tags":[],"class_list":["post-33429","post","type-post","status-publish","format-standard","hentry","category-viewpoints"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>News from Brakke Consulting<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/brakkeconsulting.com\/pt\/brakke-viewpoint-march-29-2024\/\" \/>\n<meta property=\"og:locale\" content=\"pt_PT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"News from Brakke Consulting\" \/>\n<meta property=\"og:description\" content=\"What do you think of when you see a pig?\u00a0 Do you start to salivate thinking about bacon, ham, a big juicy pork chop or a slab of ribs?\u00a0 Rick Slayman, a 62-year old Massachusetts resident with end-stage kidney disease sees pigs as a potential ticket to a dialysis-free life. On March 21, doctors at Mass General Hospital performed the first transplant of a genetically modified kidney from a pig.\u00a0 According to the Organ Procurement and Transplantation Network, approximately 27,000 kidneys were transplanted in 2023.\u00a0 However, the waitlist for human kidneys has approximately 89,000 individuals on it.\u00a0 Just think about how many people could live a productive, happy, healthy life if this operation proves to be a complete success.\u00a0 This could potentially eliminate the largest barrier to transplantation which is organ supply. The most critical obstacle to the use of animal organs in humans is organ rejection.\u00a0 The kidney used in this procedure was genetically modified by eGenesis Bio to increase human compatibility.\u00a0 eGenesis employed new technology to make 69 precise edits to the pig\u2019s DNA (snipping certain characteristics out and adding others) to try to prevent the human body from seeing the kidney as a foreign body.\u00a0 That, combined with monoclonal antibody treatments to reduce the likelihood of rejection, provide a possible pathway for animal organ transplantation. 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On March 21, doctors at Mass General Hospital performed the first transplant of a genetically modified kidney from a pig.\u00a0 According to the Organ Procurement and Transplantation Network, approximately 27,000 kidneys were transplanted in 2023.\u00a0 However, the waitlist for human kidneys has approximately 89,000 individuals on it.\u00a0 Just think about how many people could live a productive, happy, healthy life if this operation proves to be a complete success.\u00a0 This could potentially eliminate the largest barrier to transplantation which is organ supply. The most critical obstacle to the use of animal organs in humans is organ rejection.\u00a0 The kidney used in this procedure was genetically modified by eGenesis Bio to increase human compatibility.\u00a0 eGenesis employed new technology to make 69 precise edits to the pig\u2019s DNA (snipping certain characteristics out and adding others) to try to prevent the human body from seeing the kidney as a foreign body.\u00a0 That, combined with monoclonal antibody treatments to reduce the likelihood of rejection, provide a possible pathway for animal organ transplantation. 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